Publication

Vascular Protective Effect and Its Possible Mechanism of Action on Selected Active Phytocompounds: A Review

Published : 16 May 2022

Asscociate Professor Dr Tan Jun Jie
Authors : Nur Aqilah Kamaruddin , Muhammad Nazrul Hakim Abdullah, Jun Jie Tan, Vuanghao Lim, Lai Yen Fong, Siti Aisyah Abd Ghafar, Yoke Keong Yong
Title of Publication : Vascular Protective Effect and Its Possible Mechanism of Action on Selected Active Phytocompounds: A Review
Journal Name : Evidence-based Complementary and Alternative Medicine
Quartile : Q2
Impact Factor : 2.630
Link : https://downloads.hindawi.com/journals/ecam/2022/3311228.pdf
Description : Vascular endothelial dysfunction is characterized by an imbalance of vasodilation and vasoconstriction, deficiency of nitric oxide (NO) bioavailability and elevated reactive oxygen species (ROS), and proinflammatory factors. This dysfunction is a key to the early pathological development of major cardiovascular diseases including hypertension, atherosclerosis, and diabetes. Therefore, modulation of the vascular endothelium is considered an important therapeutic strategy to maintain the health of the cardiovascular system. Epidemiological studies have shown that regular consumption of medicinal plants, fruits, and vegetables promotes vascular health, lowering the risk of cardiovascular diseases. This is mainly attributed to the phytochemical compounds contained in these resources. Various databases, including Google Scholar, MEDLINE, PubMed, and the Directory of Open Access Journals, were searched to identify studies demonstrating the vascular protective effects of phytochemical compounds. The literature had revealed abundant data on phytochemical compounds protecting and improving the vascular system. Of the numerous compounds reported, curcumin, resveratrol, cyanidin-3-glucoside, berberine, epigallocatechin-3-gallate, and quercetin are discussed in this review to provide recent information on their vascular protective mechanisms in vivo and in vitro. Phytochemical compounds are promising therapeutic agents for vascular dysfunction due to their antioxidative mechanisms. However, future human studies will be necessary to confirm the clinical effects of these vascular protective mechanisms.
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