Potential of Lyophilized Platelet Concentrates for Craniofacial Tissue Regenerative Therapies

Authors :Ngah, NA (Ngah, Nurul Aida); Ratnayake, J (Ratnayake, Jithendra); Cooper, PR (Cooper, Paul R.); Dias, GJ (Dias, George J.); Tong, DC (Tong, Darryl C.); Noor, SNFM (Mohd Noor, Siti Noor Fazliah); Hussaini, HM (Hussaini, Haizal Mohd)

Titles of Publication :Potential of Lyophilized Platelet Concentrates for Craniofacial Tissue Regenerative Therapies

Journal Name :Molecules

Quartile :Q2

Impact Factor :3.267 

Link :https://doi.org/10.3390/molecules26030517

Description :The use of platelet concentrates (PCs) in oral and maxillofacial surgery, periodontology, and craniofacial surgery has been reported. While PCs provide a rich reservoir of autologous bioactive growth factors for tissue regeneration, their drawbacks include lack of utility for long-term application, low elastic modulus and strength, and limited storage capability. These issues restrict their broader application. This review focuses on the lyophilization of PCs (LPCs) and how this processing approach affects their biological and mechanical properties for application as a bioactive scaffold for craniofacial tissue regeneration.