Publication

Redox-sensitive linear and cross-linked cystamine-based polymers for colon-targeted drug delivery: design, synthesis, and characterisation

HASNIZA BINTI AMNO

Published : 21 July 2020

Authors :Yoke Mooi Ng, Siti Nur Aishah Mat Yusuf, Hock Ing Chiu, Vuanghao Lim

Titles of Publication :Redox-sensitive linear and cross-linked cystamine-based polymers for colon-targeted drug delivery: design, synthesis, and characterisation

Journal Name :Pharmaceutics

Quartile :Q1

Impact Factor :4.421

Link :10.3390/pharmaceutics12050461

Description :Cystamine-based polymers may help to achieve controlled and targeted drug delivery to the colon due to their susceptibility to breakage of the disulfide linkage in the low redox potential environment of the colon. In this study, two linear cystamine-based polymers with similar repeating units (LP1 and LP2) and a cross-linked cystamine-based polymer (BP) were synthesised and their kinetics and the various physical conditions underlying cystamine-based polymerisation were evaluated

Redox-sensitive linear and cross-linked cystamine-based polymers for colon-targeted drug delivery: design, synthesis, and characterisation

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