Dr. Doblin Anak Sandai
Publication
Transcriptomic and proteomic profiling revealed reprogramming of carbon metabolism in acetate-grown human pathogen Candida glabrata
Dr. Doblin Anak Sandai
Authors : Shu Yih Chew, Alistair J. P. Brown, Benjamin Yii Chung Lau, Yoke Kqueen Cheah, Kok Lian Ho, Doblin Sandai, Hassan Yahaya & Leslie Thian Lung Than
Titles of Publication : Transcriptomic and proteomic profiling revealed reprogramming of carbon metabolism in acetate-grown human pathogen Candida glabrata
Journal Name : Journal of Biomedical Science
Quartile : Q1
Impact Factor : 5.762
Description : Emergence of Candida glabrata, which causes potential life-threatening invasive candidiasis, has been widely associated with high morbidity and mortality. In order to cause disease in vivo, a robust and highly efficient metabolic adaptation is crucial for the survival of this fungal pathogen in human host. In fact, reprogramming of the carbon metabolism is believed to be indispensable for phagocytosed C. glabrata within glucose deprivation condition during infection. In this study, the metabolic responses of C. glabrata under acetate growth condition was explored using high-throughput transcriptomic and proteomic approaches.
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