In silico molecular docking in DNA aptamer development

Authors :Navien, TN (Navien, Tholasi Nadhan); Thevendran, R (Thevendran, Ramesh); Hamdani, HY (Hamdani, Hazrina Yusof); Tang, TH (Tang, Thean-Hock); Citartan, M (Citartan, Marimuthu)

Titles of Publication :In silico molecular docking in DNA aptamer development

Journal Name :Biochimie

Quartile :Q2 

Impact Factor : 4.079

Link :https://doi.org/10.1016/j.biochi.2020.10.005

Description : Aptamers are single-stranded DNA or RNA oligonucleotides generated by SELEX that exhibit binding affinity and specificity against a wide variety of target molecules. Compared to RNA aptamers, DNA aptamers are much more stable and therefore are widely adopted in a number of applications especially in diagnostics. The tediousness and rigor associated with certain steps of the SELEX intensify the efforts to adopt in silico molecular docking approaches together with in vitro SELEX procedures in developing DNA aptamers. Inspired by these endeavors, authors carry out an overview of the in silico molecular docking approaches in DNA aptamer generation, by detailing the stepwise procedures as well as shedding some light on the various softwares used.