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Sphingosine kinase and sphingosine-1-phosphate receptor signaling pathway in inflammatory gastrointestinal disease and cancers: a novel therapeutic target
Authors :Olga A Sukocheva, Hideki Furuya, Mei Li Ng, Markus Friedemann, Mario Menschikowski, Vadim V Tarasov, Vladimir N Chubarev, Sergey G Klochkov, Margarita E Neganova, Arduino A Mangoni, Gjumrakch Aliev, Anupam Bishayee
Titles of Publication :Sphingosine kinase and sphingosine-1-phosphate receptor signaling pathway in inflammatory gastrointestinal disease and cancers: a novel therapeutic target
Journal Name :Pharmacology and Therapeutics
Quartile :Q1
Impact Factor :10.557
Description :In this review, authors analyze the mechanisms of SphK/S1P signaling in GI tissues and critically appraise recent studies on the role of SphK/S1P/S1PR in inflammatory GI disorders and cancers. The potential role of SphK/S1PR inhibitors in the prevention and treatment of inflammation-mediated GI diseases, including GI cancer, is also evaluated
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