Therapeutic effects of menstrual blood-derived endometrial stem cells on mouse models of streptozotocin-induced type 1 diabetes

Authors : Yu-Liang Sun, Ling-Rui Shang, Rui-Hong Liu, Xin-Yi Li, Sheng-Hui Zhang, Ya-Kun Ren, Kang Fu, Hong-Bin

Cheng, Badrul Hisham Yahaya, Yan-Li Liu, Jun-Tang Lin

Title of Publication : Therapeutic effects of menstrual blood-derived endometrial stem

cells on mouse models of streptozotocin-induced type 1 diabetes

Journal Name : World Journal of Stem Cells

Quartile : Q2

Impact Factor : 5.326

Link : https://www.wjgnet.com/1948-0210/full/v14/i1/104.htm

Description : Type 1 diabetes (T1D), a chronic metabolic and autoimmune disease, seriously endangers human health. In recent years, mesenchymal stem cell (MSC) transplantation has become an effective treatment for diabetes. Menstrual blood-derived endometrial stem cells (MenSC), a novel MSC type derived from the decidual endometrium during menstruation, are expected to become promising seeding cells for diabetes treatment because of their noninvasive collection procedure, high proliferation rate and high immunomodulation capacity. The aim of this study is to comprehensively compare the effects of MenSC and umbilical cord-derived MSC (UcMSC) transplantation on T1D treatment, to further explore the potential mechanism of MSC-based therapies in T1D, and to provide support for the clinical application of MSC in diabetes treatment.