Authors : Rabiatul Basria S M N Mydin, Srimala Sreekantan, Darius Widera, Khairul Arifah Saharudin, Roshasnorlyza Hazan, Mustafa Fadzil Farid Wajidi
Title of Publication : Genome-nanosurface interaction of titania nanotube arrays: evaluation of telomere, telomerase and NF-kB activities on an epithelial cell model
Journal Name : RSC Advances
Quartile : Q2
Impact Factor : 3.361
Link : https://pubs.rsc.org/en/content/articlepdf/2022/ra/d1ra05325f
Description : Titanium dioxide nanotube arrays (TNAs) provide a promising platform for medical implants and nanomedicine applications. The present cell–TNA study has provided profound understanding on protection of genome integrity via telomere, telomerase and NF-kB activities using an epithelial cell model. It has been revealed in this study that cell–TNA interaction triggers the telomere shortening activity and inhibition of telomerase activity at the mRNA and protein level. The present work supported that the cell–TNA stimulus might involve controlled transcription and proliferative activities via NBN and TERF21P mechanisms. Moreover, inhibition of NF-kB may promote molecular sensitivity via senescence-associated secretory phenotype activities and might result in reduced inflammatory response which would be good for cell and nanosurface adaptation activities. Thus, this nanomaterial-molecular knowledge is beneficial for further nanomaterial characterization and advanced medical application.