Human umbilical cord mesenchymal stem cell-derived extracellular vesicles ameliorate airway inflammation in a rat model of chronic obstructive pulmonary disease (COPD)

Authors :Ridzuan, N (Ridzuan, Noridzzaida); Zakaria, N (Zakaria, Norashikin); Widera, D (Widera, Darius); Sheard, J (Sheard, Jonathan); Morimoto, M (Morimoto, Mitsuru); Kiyokawa, H (Kiyokawa, Hirofumi); Isa, SAM (Mohd Isa, Seoparjoo Azmel); Singh, GKC (Chatar Singh, Gurjeet Kaur); Then, KY (Then, Kong-Yong); Ooi, GC (Ooi, Ghee-Chien); Yahaya, BH (Yahaya, Badrul Hisham)

Titles of Publication :Human umbilical cord mesenchymal stem cell-derived extracellular vesicles ameliorate airway inflammation in a rat model of chronic obstructive pulmonary disease (COPD)

Journal Name :Stem Cell Research & Therapy

Quartile :Q1

Impact Factor :5.116

Link :10.1186/s13287-020-02088-6

Description :Both transplantation of hUC-MSCs and application of EVs resulted in a reduction of peribronchial and perivascular inflammation, alveolar septal thickening associated with mononuclear inflammation, and a decreased number of goblet cells. Moreover, hUC-MSCs and EVs ameliorated the loss of alveolar septa in the emphysematous lung of COPD rats and reduced the levels of NF-?B subunit p65 in the tissue. Subsequent microarray analysis revealed that both hUC-MSCs and EVs significantly regulate multiple pathways known to be associated with COPD. In conclusion, authors show that hUC-MSC-derived EVs effectively ameliorate by COPD-induced inflammation. Thus, EVs could serve as a new cell-free-based therapy for the treatment of COPD.